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MSD IMPROVE-IT l?pt?|?m?ˆX}m?FDA, U.S. Food and Drug Administration) 2015D???Ȝt?tǠѰ?tɸd(1? ?? \?Ȕ ??t?`?|?\?QǝD?h`?Ĭt? ֬?tǠѰ?tɸd@?֝?X֐??D?LDL-C X|?0?t?tǔƕ?h??}?\?x??. tLj?l|?Ȭ\?XՄ?X?Y? ? |??Eugene Braunwald) @?l?Y?\?ά?Robert Califf) ? IMPROVE-IT l? ?|?Ĭ }??D?L? Ĭ }?D?ų<\?`?L???t?`t?T?D?<\?Ь p? t? D?\?Ld?X??\?|???\?l\?<\??\?tp? IMPROVE-IT pt?є?LDL-CD?D?@?XL?¤Д? \?ɔ\?Y???X??t??X? й. IMPROVE-IT l? 买 @?LDL-C X֐p?DP? IMPROVE-IT l??DP??X֐pX?LDL-C XΔ?买 X? l?1D? LDL-C XΔ?tǠѰp??53 mg/dL, p??70 mg/dLt??X?LDL-C X?(tǔ?17 mg/dLt? IMPROVE-IT l|?2005D?‘LjD?, ??ٳ?p?X֐????t????买 @?<\?̸?x? t?m??? ??LDL-C \?XΔ?<70 mg/dLt? t??\?Ĭ }??\??? l??tǘ?@?LDL-C X??X???DP??? (*DŘ?\?8?. \? ????X̸p??LDL-C DP??l?IDEAL (2005)TNT (2005)PROVE-IT (2004)A to Z (2004)IMPROVE-IT (2014)LDL-C DP??(mg/dL)?104 vs. 81101 vs. 7795 vs. 6277 vs. 6370 vs. 53*Blazing, et al. Am H J 2014; 168: 205-212. ? ??\?\???PROVE-IT ?A to Z|?xX? @?<\?\???  ‘ X? LDL-C }?95 mg/dL? ‘ ?X̸|?@?t?Ŕ X֐?l?<ՐX?}?2/3)pX? LDL-C 101 mg/dLt? t?? X??X̸|?XX?X֐pX? 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